全文获取类型
收费全文 | 107篇 |
免费 | 28篇 |
国内免费 | 13篇 |
专业分类
化学 | 37篇 |
力学 | 5篇 |
综合类 | 1篇 |
数学 | 20篇 |
物理学 | 85篇 |
出版年
2023年 | 2篇 |
2022年 | 4篇 |
2021年 | 12篇 |
2020年 | 8篇 |
2019年 | 11篇 |
2017年 | 7篇 |
2016年 | 6篇 |
2015年 | 4篇 |
2014年 | 12篇 |
2013年 | 3篇 |
2012年 | 9篇 |
2011年 | 4篇 |
2010年 | 7篇 |
2009年 | 10篇 |
2008年 | 3篇 |
2007年 | 8篇 |
2006年 | 5篇 |
2005年 | 1篇 |
2004年 | 3篇 |
2003年 | 6篇 |
2002年 | 3篇 |
2001年 | 3篇 |
2000年 | 2篇 |
1999年 | 2篇 |
1998年 | 1篇 |
1997年 | 3篇 |
1996年 | 1篇 |
1995年 | 2篇 |
1994年 | 1篇 |
1992年 | 1篇 |
1991年 | 1篇 |
1989年 | 1篇 |
1986年 | 1篇 |
1985年 | 1篇 |
排序方式: 共有148条查询结果,搜索用时 244 毫秒
1.
The method of condensed matter physics is applied to reason out the problem of Na transport through a biological membrane.
A similiarity of gating process in Na ion channel to the superionic phase transition is discussed. A possible microscopic
mechanism is suggested. 相似文献
2.
《印度化学会志》2021,98(9):100122
Salophen is a weakly fluorescent Schiff base which forms emissive co-ordination complexes with Zn2+ and Al3+. The complex with Al3+ is significantly more fluorescent than that with Zn2+, presumably because the dimeric complex with Zn2+ is associated with additional nonradiative channels. This contention has been put to test, through a careful investigation of excited state dynamics of the anionic form of salophen (Sal2−), which is the form in which the ligand exists in the complexes. The emissive excited state of the anion (Sal2−) has been found to be solvated and conformationally relaxed, over tens of picosecond. It is significantly more fluorescent than the neutral compound, with fluorescence lifetime that is longer by almost two orders of magnitude. Fluorescence lifetime of the anion is in fact longer than that of the complex with Zn2+ and slightly less than that of the complex with Al3+. So, the earlier hypothesis about additional nonradiative deactivation pathways in the Zn2+ complex gains credence from the present study. 相似文献
3.
Voltage‐Driven Reversible Insertion into and Leaving from a Lipid Bilayer: Tuning Transmembrane Transport of Artificial Channels 下载免费PDF全文
Wen Si Prof. Zhan‐Ting Li Prof. Jun‐Li Hou 《Angewandte Chemie (International ed. in English)》2014,53(18):4578-4581
Three new artificial transmembrane channel molecules have been designed and synthesized by attaching positively charged Arg‐incorporated tripeptide chains to pillar[5]arene. Fluorescent and patch‐clamp experiments revealed that voltage can drive the molecules to insert into and leave from a lipid bilayer and thus switch on and off the transport of K+ ions. One of the molecules was found to display antimicrobial activity toward Bacillus subtilis with half maximal inhibitory concentration (IC50) of 10 μM which is comparable to that of natural channel‐forming peptide alamethicin. 相似文献
4.
Atomic-level studies of protein activity represent a significant challenge as a result of the complexity of conformational changes occurring on wide-ranging timescales, often greatly exceeding that of even the longest simulations. A prime example is the elucidation of protein allosteric mechanisms, where localized perturbations transmit throughout a large macromolecule to generate a response signal. For example, the conversion of chemical to electrical signals during synaptic neurotransmission in the brain is achieved by specialized membrane proteins called pentameric ligand-gated ion channels. Here, the binding of a neurotransmitter results in a global conformational change to open an ion-conducting pore across the nerve cell membrane. X-ray crystallography has produced static structures of the open and closed states of the proton-gated GLIC pentameric ligand-gated ion channel protein, allowing for atomistic simulations that can uncover changes related to activation. We discuss a range of enhanced sampling approaches that could be used to explore activation mechanisms. In particular, we describe recent application of an atomistic string method, based on Roux's “swarms of trajectories” approach, to elucidate the sequence and interdependence of conformational changes during activation. We illustrate how this can be combined with transition analysis and Brownian dynamics to extract thermodynamic and kinetic information, leading to understanding of what controls ion channel function. © 2019 Wiley Periodicals, Inc. 相似文献
5.
George Khelashvili Xiaolu Cheng Maria E. Falzone Milka Doktorova Alessio Accardi Harel Weinstein 《Journal of computational chemistry》2020,41(6):538-551
Recent discoveries about functional mechanisms of proteins in the TMEM16 family of phospholipid scramblases have illuminated the dual role of the membrane as both the substrate and a mechanistically responsive environment in the wide range of physiological processes and genetic disorders in which they are implicated. This is highlighted in the review of recent findings from our collaborative investigations of molecular mechanisms of TMEM16 scramblases that emerged from iterative functional, structural, and computational experimentation. In the context of this review, we present new MD simulations and trajectory analyses motivated by the fact that new structural information about the TMEM16 scramblases is emerging from cryo-EM determinations in lipid nanodiscs. Because the functional environment of these proteins in in vivo and in in vitro is closer to flat membranes, we studied comparatively the responses of the membrane to the TMEM16 proteins in flat membranes and nanodiscs. We find that bilayer shapes in the nanodiscs are very different from those observed in the flat membrane systems, but the function-related slanting of the membrane observed at the nhTMEM16 boundary with the protein is similar in the nanodiscs and in the flat bilayers. This changes, however, in the bilayer composed of longer-tail lipids, which is thicker near the phospholipid translocation pathway, which may reflect an enhanced tendency of the long tails to penetrate the pathway and create, as shown previously, a nonconductive environment. These findings support the correspondence between the mechanistic involvement of the lipid environment in the flat membranes, and the nanodiscs. © 2019 Wiley Periodicals, Inc. 相似文献
6.
本文从理论上分析了低激发密度下,选通光分别为脉冲光和连续光时,孔深随时间的变化,得到可以通过脉冲光烧孔、连续光选通的方法缩短烧孔时间.应用BaFCl0.5Br0.5:Sm2+(2%)进行了实验,分析了单脉冲烧孔的孔深. 相似文献
7.
8.
9.
The paper demonstrates conceptual parallels and relationships between intellectual capital measurement methods and the evaluation
of quality in clinical laboratories in the Slovak Republic. It explores further the contextual links of those parallels with
the tangibility (or intangibility) of quality indicators of laboratory diagnostics. It also highlights the problems which
laboratory staff in Slovakia are confronted with.
Presented at the conference Quality in the Spotlight, March 2007, Antwerp, Belgium. 相似文献
10.